Rethinking Carbohydrate Synthesis: Stereoretentive Reactions of Anomeric Stannanes

Anomeric Hydroperoxides; Synthesis, Enantioselective Epoxidation

Some time ago we reported the oxidation of 2,3-unsaturated hexopyranosides and 2-Cmethylene glycosides with hydrogen peroxide in the presence of molybdenum trioxide catalyst to give the corresponding anomeric hydroperoxides 1-5. Relatively stable hydroperoxides 1-5 were used for enantioselective oxidation of prochiral alcohols and sulfides in the presence of Ti(OiPr)4 with stereoselectivities v...

Sustainable synthesis of thioimidazoles via carbohydrate-based multicomponent reactions.

The synthesis of diversely functionalized thioimidazoles through a modern variant of the Marckwald reaction is presented. This new protocol utilizes unprotected carbohydrates as well as simple amine salts as sustainable and biorenewable starting materials. Importantly it was discovered that a bifurcated reaction pathway results from using aldoses and ketoses respectively, yielding distinct reac...

Rethinking credible evidence synthesis.

Government regulators and systematic reviewers both aim to generate an accurate understanding of the effects of interventions. However, the methods they use, and the evidence they consider, are different. Although both focus on randomised clinical trials for determining safety and efficacy, the mostly academic community of systematic reviewers generally get their data from published reports of ...

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

Rethinking the numbers on adverse drug reactions.